VISDB - VIS Detail

Basic Information

VIS ID

TVIS44002377

Fusion event

HTLV-1-IL12RB2 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr1

Cytoband

p31.3

Reference genome

GRCh37/hg19

Start

67820104/67354421 (Hg38)

End

67820104/67354421 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA1L

Target gene

IL12RB2

miRNAs that regulate target gene

hsa-mir-7-5p ; hsa-mir-625-5p ; hsa-mir-3180-5p ; hsa-mir-493-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-129-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-151a-3p

Nearest miRNA

hsa-mir-101-1/Upstream/725904; hsa-mir-11399/Downstream/829097;

Nearest TSS

ENST00000473358/Upstream/27652; ENST00000465396/Downstream/25507;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/219389, chr1-CpG: 139/Downstream/75031

Upstream sequence

GAAGAACCAGAGATAAGGAAGAAGTTGAAGACAAAGGAGAGGGAGGAATAATAGAATAAAGTCCCTGGGGAGATGGGAGATGATGAGGAGCCAGTGACCA

Downstream sequence

AAAGAGGGAAGAGGAACACTTCATCCTCTGAGAGTGGACAGAGGACCATTGATCATAGAATGCTAAGAATGAGGTTGATGCAGAGATCACGTCAGGAGGG

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.