Basic Information
VIS ID
TVIS44002381
Fusion event
HTLV-1-MARCH5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.33
Reference genome
GRCh37/hg19
Start
94061962/92302205 (Hg38)
End
94061962/92302205 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
MARCH5
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-let-7e-5p ; hsa-mir-34a-5p ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-8485 ; hsa-mir-3941 ; hsa-mir-4719 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p
Nearest miRNA
hsa-mir-107/Upstream/2709378; hsa-mir-1287/Downstream/3762110;
Nearest TSS
ENST00000439456/Upstream/11042; ENST00000462465/Downstream/6273;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/10550, chr10-CpG: 42/Downstream/118353
Upstream sequence
tatactgtattgttatgaaataataacaaggaaaagtccctccatgttcagtacagactcttttttttccaaatgtattttacctgagattagttgaatg
Downstream sequence
aacagatgcagaaccctcagttggagggctgactgTATTCTCACCTTTTCTTTTTGGTAATGTGTCATGATTGTGGTTATATGTCTTTGATAGATCCAGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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