Basic Information
VIS ID
TVIS44002392
Fusion event
HTLV-1-AMPD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
10474532/10452985 (Hg38)
End
10474532/10452985 (Hg38)
Orient
+
Location type
Intronic
Target gene
AMPD3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-7975 ; hsa-mir-3143 ; hsa-mir-8485 ; hsa-mir-543 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-3151-5p ; hsa-mir-4265 ; hsa-mir-4296 ; hsa-mir-4322 ; hsa-mir-4447 ; hsa-mir-4472 ; hsa-mir-491-5p ; hsa-mir-6742-5p ; hsa-mir-6759-5p ; hsa-mir-6796-5p
Nearest miRNA
hsa-mir-210/Upstream/1362606; hsa-let-7a-2/Downstream/55285;
Nearest TSS
ENST00000527297/Upstream/2043; ENST00000531227/Downstream/2335;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1798, chr11-CpG: 70/Downstream/87693
Upstream sequence
aaggtcatacaactaagtggtggaacaggattcaaatgcagggagtctagctggagttttttttgttgttgtttgtttgtttgaaatggagtctcactct
Downstream sequence
gtcacccaggctggagtgcagtggcacaatctcagctcactgcaacctccacctcccgggttcaagcgattctcctgcctcagcttcccaagtagctggg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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