Basic Information
VIS ID
TVIS44002393
Fusion event
HTLV-1-XRRA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
74659027/74947982 (Hg38)
End
74659027/74947982 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
XRRA1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-552-5p ; hsa-mir-4677-5p ; hsa-mir-580-3p ; hsa-mir-22-5p ; hsa-mir-526b-5p ; hsa-mir-2116-5p ; hsa-mir-539-5p ; hsa-mir-7114-3p ; hsa-mir-1180-5p ; hsa-mir-660-5p ; hsa-mir-4286 ; hsa-mir-7108-3p ; hsa-mir-4313 ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-642a-5p ; hsa-mir-4771 ; hsa-mir-6832-3p ; hsa-mir-1273g-5p ; hsa-mir-1825 ; hsa-mir-18b-3p ; hsa-mir-199a-5p ; hsa-mir-199b-5p ; hsa-mir-203a-5p ; hsa-mir-3157-3p ; hsa-mir-3180-5p ; hsa-mir-371b-3p ; hsa-mir-648
Nearest miRNA
hsa-mir-10392/Upstream/227645; hsa-let-7a-2/Downstream/387110;
Nearest TSS
ENST00000527297/Upstream/11066; ENST00000527290/Downstream/1038;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/198469, chr11-CpG: 51/Downstream/904
Upstream sequence
cccggctcatttttgtatttttagtagagacggggtttcaccatgttggccaggctggtctttaactcctgacctcaggtgatccgcctgccttggcggg
Downstream sequence
gattacaaccatgagcccccacgcccggccGAGATAATTATTTTCACATgaattttggcttccccaagacaagtttttgtctgttttattcagggatata
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate