Basic Information
VIS ID
TVIS44002395
Fusion event
HTLV-1-FOXJ2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
GRCh37/hg19
Start
8202366/8049770 (Hg38)
End
8202366/8049770 (Hg38)
Orient
+
Location type
Intronic
Target gene
FOXJ2
miRNAs that regulate target gene
hsa-mir-760 ; hsa-mir-423-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-142-5p ; hsa-mir-106b-5p ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-20b-5p ; hsa-mir-520e ; hsa-mir-520a-3p ; hsa-mir-526b-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-519d-3p ; hsa-mir-520d-3p ; hsa-mir-302e ; hsa-mir-5590-3p ; hsa-mir-4796-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-197-3p ; hsa-let-7f-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-1185-2-3p ; hsa-mir-193b-5p ; hsa-mir-3170 ; hsa-mir-3202 ; hsa-mir-4271 ; hsa-mir-4475 ; hsa-mir-4492 ; hsa-mir-4498 ; hsa-mir-4505 ; hsa-mir-4725-3p ; hsa-mir-4731-5p ; hsa-mir-4747-5p ; hsa-mir-483-5p ; hsa-mir-5001-5p ; hsa-mir-5196-5p ; hsa-mir-5691 ; hsa-mir-5787 ; hsa-mir-625-5p ; hsa-mir-6780b-5p ; hsa-mir-6795-5p ; hsa-mir-6805-3p ; hsa-mir-6813-5p ; hsa-mir-6855-5p ; hsa-mir-6887-5p ; hsa-mir-7155-5p ; hsa-mir-7515 ; hsa-mir-762 ; hsa-mir-92b-5p
Nearest miRNA
hsa-mir-141/Upstream/1085579; hsa-let-7i/Downstream/1189697;
Nearest TSS
ENST00000382841/Upstream/16410; ENST00000539192/Downstream/198;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/16750, chr12-CpG: 38/Downstream/32323
Upstream sequence
AGTGACCCAAATTGAGCAGTGGAACTAGTTTATCAGTTGACTGAATATCTGTTGAATCAGTGAAGTCCTAAACTGAAAAATGCAAAAGAAATAGACTGTA
Downstream sequence
TGATTCCTTTTTAGACCTCAGTTTGGGAGATCAGAATTGTTTAAGAAAAGGGAGGAGATTTGTTAGAGAAAGGCTGTATTTTAAATTTGCGTCTCAGTAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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