Basic Information
VIS ID
TVIS44002426
Fusion event
HTLV-1-DOCK10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q36.2
Reference genome
GRCh37/hg19
Start
225820558/224955841 (Hg38)
End
225820558/224955841 (Hg38)
Orient
+
Location type
Intronic
Target gene
DOCK10
miRNAs that regulate target gene
hsa-mir-142-3p ; hsa-mir-132-3p ; hsa-mir-26b-5p ; hsa-mir-21-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-10b/Upstream/5049276; hsa-mir-1244-1/Downstream/54620;
Nearest TSS
ENST00000437798/Upstream/8776; ENST00000636099/Downstream/26586;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/370070, chr2-CpG: 114/Downstream/86095
Upstream sequence
TGCAGTAAATTCTTGACATTTTGAAGTCCAGTAGTTAAGGTCCCCAATTAAAGGGCAAATTAACCTCTGGGTATGTGTTCTGCACCTCACTAGGTAAACA
Downstream sequence
AGAAGAACTGAAATAGCAGAGAAACAAGAATTGGATACCTCTCATAAGGGCACCCATATGTATTTAATCTAGTTTATGAGAATGACTCTCTGTCAAACAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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