Basic Information
VIS ID
TVIS44002429
Fusion event
HTLV-1-GPR75-ASB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
54065161/53838024 (Hg38)
End
54065161/53838024 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2D ; FRA2H
Target gene
GPR75-ASB3
miRNAs that regulate target gene
hsa-mir-342-3p ; hsa-mir-1285-5p ; hsa-mir-204-3p ; hsa-mir-2681-5p ; hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-4646-5p ; hsa-mir-4747-5p ; hsa-mir-5196-5p ; hsa-mir-7849-3p
Nearest miRNA
hsa-mir-1301/Upstream/1135409; hsa-mir-10b/Downstream/11098;
Nearest TSS
ENST00000437798/Upstream/50414; ENST00000606082/Downstream/21896;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/50663, chr2-CpG: 60/Downstream/21615
Upstream sequence
ctctcagagttgatgaaaatttcaaatggacaaccagaatggatgcctactattaacacttctgttcaaccttgtactgaatttctagctaaccatgtaa
Downstream sequence
gacaagaaaaggtgaaggtgtaaggcttagaatggaagaaacaaaaccattattgccaaatgcagtgcctcacacctgtaatcccaacactgggatgcca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate