Basic Information
VIS ID
TVIS44002436
Fusion event
HTLV-1-MICALL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
38310521/37914514 (Hg38)
End
38310521/37914514 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
MICALL1
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-1301-3p ; hsa-mir-423-5p ; hsa-mir-423-3p ; hsa-mir-93-5p ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-378a-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-3653-5p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-141-5p
Nearest miRNA
hsa-mir-1286/Upstream/66740; hsa-let-7a-3/Downstream/53049;
Nearest TSS
ENST00000624155/Upstream/7632; ENST00000454685/Downstream/11333;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/7650, chr22-CpG: 45/Downstream/38981
Upstream sequence
cggggtttcaccatgttggccaggctggtctcgaattcctgacctcaggtgatccacccacctcagcctcccaaagtgctgggattacaggcatgagcca
Downstream sequence
ctgcacccagccATCTTTTCTTTCATtatatatatatatgtatatatatacatgcatatacatatatatgtacatatattatgtgtatatatGCGTGCGC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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