Basic Information
VIS ID
TVIS44002440
Fusion event
HTLV-1-NEK4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
52762612/52728596 (Hg38)
End
52762612/52728596 (Hg38)
Orient
+
Location type
Intronic
Target gene
NEK4
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-3942-3p ; hsa-mir-383-3p ; hsa-mir-4257 ; hsa-mir-6847-5p ; hsa-mir-2909 ; hsa-mir-548s ; hsa-mir-3162-5p ; hsa-mir-3926 ; hsa-mir-4738-3p ; hsa-mir-3190-5p ; hsa-mir-7162-3p ; hsa-mir-544b ; hsa-mir-6849-3p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-1288-5p ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6760-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-3714
Nearest miRNA
hsa-let-7g/Upstream/434288; hsa-mir-12124/Downstream/117867;
Nearest TSS
ENST00000440867/Upstream/22453; ENST00000480409/Downstream/17518;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/22186, chr3-CpG: 61/Downstream/41947
Upstream sequence
tcttcataagatgaggatgtacgtcacctcaggactaccatgataattgtgttaactgtacaaattgattgtaaaacatgtgtgtttgaacaatatgaag
Downstream sequence
tcagtgcaccttgaaaaagaacagaataacagcgattttcagggaacaagggaagacaaccataaggtctgactgcctgaggggtcgggcaaaatagagc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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