Basic Information
VIS ID
TVIS44002446
Fusion event
HTLV-1-ILDR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
121768125/122049278 (Hg38)
End
121768125/122049278 (Hg38)
Orient
+
Location type
Intronic
Target gene
ILDR1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4330 ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-1303 ; hsa-mir-3674 ; hsa-mir-7977 ; hsa-mir-6832-5p ; hsa-mir-4732-5p ; hsa-mir-1304-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-4307 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-483-5p
Nearest miRNA
hsa-let-7g/Upstream/999563; hsa-mir-12124/Downstream/1112516;
Nearest TSS
ENST00000440867/Upstream/27020; ENST00000478390/Downstream/6088;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/26875, chr3-CpG: 74/Downstream/134617
Nearby gene
CD86(+6084) ;
Upstream sequence
aattttccaattttccttctaatattgatttctggtttcattccattgtgattggaaaaggtacttggtattatttcaatcttaaatgtgataggacttg
Downstream sequence
ttttgtgatccagcatgtgatctattaaaaaaaaatgttctgtgtgttcttgggaaaaatgtgaattcttctgctattaggtagaatgttctgtgtatgt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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