Basic Information
VIS ID
TVIS44002449
Fusion event
HTLV-1-SH3BP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
2799054/2797327 (Hg38)
End
2799054/2797327 (Hg38)
Orient
+
Location type
Intronic
Target gene
SH3BP2
miRNAs that regulate target gene
hsa-mir-939-5p ; hsa-mir-331-3p ; hsa-mir-197-3p ; hsa-mir-3613-3p ; hsa-mir-548c-3p ; hsa-mir-5693 ; hsa-mir-4668-5p ; hsa-mir-5096 ; hsa-mir-513b-5p ; hsa-mir-627-3p ; hsa-mir-186-3p ; hsa-mir-6895-5p ; hsa-mir-1972 ; hsa-mir-6514-3p ; hsa-mir-7977 ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-4284 ; hsa-mir-3202 ; hsa-mir-6847-3p ; hsa-mir-6811-3p ; hsa-mir-4755-3p ; hsa-mir-3179 ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-5582-5p ; hsa-mir-1827 ; hsa-mir-203b-3p ; hsa-mir-4649-3p ; hsa-mir-665 ; hsa-mir-6808-5p ; hsa-mir-6893-5p ; hsa-mir-708-3p ; hsa-mir-7158-3p ; hsa-mir-7160-5p ; hsa-mir-873-5p ; hsa-mir-940 ; hsa-mir-129-5p ; hsa-mir-29b-2-5p ; hsa-mir-659-3p
Nearest miRNA
hsa-mir-4800/Upstream/547171; hsa-mir-12113/Downstream/3125948;
Nearest TSS
ENST00000502981/Upstream/3168; ENST00000508338/Downstream/1237;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/3587, chr4-CpG: 112/Downstream/20445
Upstream sequence
GGAAGGGATCAGGGGTCATTCTGGGAGCCTGGAATGCTGGGCGGTCCTTGGCTTTTTCTCAGCCTTGGGAGTCTGGGGCAGTGGTGCGCCTTTACCACCC
Downstream sequence
ACCCTGGTTTCTGCCTCTGGGGCAGTGGTGGACCTCCTTCAGAAGGCTGCTGCCCAGCCCCGGGCCCCACTCATGCAACACTGGGTGCCTGTGTACTGGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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