Basic Information
VIS ID
TVIS44002456
Fusion event
HTLV-1-ROS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
117668373/117347210 (Hg38)
End
117668373/117347210 (Hg38)
Orient
+
Location type
Intronic
Target gene
ROS1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-33a-5p ; hsa-mir-300
Nearest miRNA
hsa-mir-10398/Upstream/10562990; hsa-mir-1202/Downstream/1721837;
Nearest TSS
ENST00000381078/Upstream/9870; ENST00000533950/Downstream/78645;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/76094, chr6-CpG: 113/Downstream/135124
Nearest cancer related gene
ROS1(OG, No orient, 0)
Upstream sequence
tgggattttcattgggattttattgaatctatagataagttgagaagaaatgacatcttgacaatattgagtcttcctatctatgacatggaatatctct
Downstream sequence
atacttatttagcactttgatttctttcatcagggttttatagtttttctcatatagatttttgtgcatatgctgttagatttatacctaagtatttcat
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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