Basic Information
VIS ID
TVIS44002490
Fusion event
HTLV-1-SCD5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.22
Reference genome
GRCh37/hg19
Start
83708828/82787675 (Hg38)
End
83708828/82787675 (Hg38)
Orient
-
Location type
Intronic
Target gene
SCD5
miRNAs that regulate target gene
hsa-mir-140-3p ; hsa-mir-324-5p ; hsa-mir-30c-5p ; hsa-mir-92a-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-9-5p ; hsa-mir-4267 ; hsa-mir-675-5p ; hsa-mir-4466 ; hsa-mir-4746-3p ; hsa-mir-511-5p ; hsa-mir-6885-3p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-6502-5p ; hsa-mir-1301-5p ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p ; hsa-mir-4637 ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-1247-3p ; hsa-mir-25-5p ; hsa-mir-3160-3p ; hsa-mir-4327 ; hsa-mir-4487 ; hsa-mir-455-3p ; hsa-mir-4722-5p ; hsa-mir-4768-3p ; hsa-mir-558 ; hsa-mir-6087 ; hsa-mir-6499-3p ; hsa-mir-6516-5p
Nearest miRNA
hsa-mir-12113/Upstream/34245; hsa-mir-1243/Downstream/2934793;
Nearest TSS
ENST00000502981/Upstream/166238; ENST00000514440/Downstream/11097;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/225737, chr4-CpG: 118/Downstream/10181
Upstream sequence
TGGCtgctgtggtctgaatgtttgtcttccctccaaaattcctatgttgaaatccttaccttcaaggtgttggtattaggaggtggggctttggggaggt
Downstream sequence
aattaggtcatgaggatggaaccatcaggaatgggattagtgccctctaaggcactaagaaaaggCTGGTGggctagactcagtgactcatgcctgtaag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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