Basic Information
VIS ID
TVIS44002503
Fusion event
HTLV-1-OSBPL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
24971484/24931865 (Hg38)
End
24971484/24931865 (Hg38)
Orient
-
Location type
Intronic
Target gene
OSBPL3
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-4762-3p ; hsa-mir-3192-3p ; hsa-mir-4662a-5p ; hsa-mir-3151-3p ; hsa-mir-6890-3p ; hsa-mir-3163 ; hsa-mir-449b-3p ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-6499-3p ; hsa-mir-539-5p ; hsa-mir-6838-5p ; hsa-mir-4519 ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-548e-5p ; hsa-mir-4712-3p ; hsa-mir-4757-3p ; hsa-mir-4517 ; hsa-mir-181d-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-1183/Upstream/3460719; hsa-mir-10399/Downstream/1018054;
Nearest TSS
ENST00000635602/Upstream/13772; ENST00000607375/Downstream/48323;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/173997, chr7-CpG: 134/Downstream/47515
Upstream sequence
AGGAAGGGGATGTAAGGAAATAAAGAGAAGTATGAAACAGCATGTGAAAAAGCATTTTCTGATGAACAACAAACACTTGCATCAACAAGACTGATACTGT
Downstream sequence
CTCAAATGTGGTCCTGAGCCAGCAATATATggggaagctgaggcttaatggaaaaacattaggagttagaaaacctgggctctcatcctcactctcccac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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