Basic Information
VIS ID
TVIS44002504
Fusion event
HTLV-1-KBTBD7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
GRCh37/hg19
Start
41766819/41192683 (Hg38)
End
41766819/41192683 (Hg38)
Orient
-
Location type
Exonic
Target gene
KBTBD7
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-877-3p ; hsa-mir-2681-5p ; hsa-mir-4652-3p ; hsa-mir-4677-3p ; hsa-mir-4679 ; hsa-mir-4743-3p
Nearest miRNA
hsa-mir-2276/Upstream/91583; hsa-mir-1267/Downstream/375603;
Nearest TSS
ENST00000623511/Upstream/59672; ENST00000483215/Downstream/1883;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/59699, chr13-CpG: 80/Downstream/1008
Upstream sequence
GTTGTGGGTCTCTGAATCCAAAGGAATATTACTAATCCGCCTCCATTCTCCCCTAGCTGGGTTGTAGACCTTCATGACTGGGATGTCACAGATACAATAG
Downstream sequence
ATTTCATCATTGAAGACACATGCTTCCTGAAAGTCACTACGTTTAAGAGAAGCACAGTTCAGCCACATATTGTGGCTAGGATCATAGCAAAGCATGCGCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate