Basic Information
VIS ID
TVIS44002505
Fusion event
HTLV-1-C18orf21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
33555971/35976008 (Hg38)
End
33555971/35976008 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
C18orf21
miRNAs that regulate target gene
hsa-mir-4652-3p ; hsa-mir-367-5p ; hsa-mir-1267
Nearest miRNA
hsa-mir-1-2/Upstream/41866; hsa-mir-122/Downstream/1681127;
Nearest TSS
ENST00000575820/Upstream/3223; ENST00000541190/Downstream/17155;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/3019, chr18-CpG: 65/Downstream/91094
Upstream sequence
GAAAGAAGAGATAGAATATTGAAGTGAGTATGGAATTCGGTTTCTTAGTTCTTGGAGAATTGTATTTTTCAAAAATCATTACTGCCACATATTTGGAAAA
Downstream sequence
TGTTCTTAAATGGGAAGACAGCAAATGCTGCCTCACTATCTTGCAGTGTTTtgccctcatgaagcttacattctaatgTATTTTAATCAGAAGTCAGCTA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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