Basic Information
VIS ID
TVIS44002515
Fusion event
HTLV-1-SIRPG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p13
Reference genome
GRCh37/hg19
Start
1629645/1648999 (Hg38)
End
1629645/1648999 (Hg38)
Orient
+
Location type
Intronic
Target gene
SIRPG
miRNAs that regulate target gene
hsa-mir-4736 ; hsa-mir-7150 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p
Nearest miRNA
hsa-mir-6869/Upstream/256038; hsa-mir-1-1/Downstream/1003778;
Nearest TSS
ENST00000382410/Upstream/15373; ENST00000400068/Downstream/2378;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/181915, chr20-CpG: 30/Downstream/86685
Upstream sequence
cttcaactcacctgatctgtagaagggggtgacaacaGGTCTTGAAAATGAGCACTGAAAATCACACCTGATTGTTGCTCAAAGAATGGAAGGTGTTACT
Downstream sequence
ATTGAGTTATTGTCACACATCAGGGGATGAGGGAGGTCCATGTTGTACTCACCACCCAAAGCCATCTCAGTGCCTGGTCCAGACTTAAACTCCACGTTCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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