Basic Information
VIS ID
TVIS44002522
Fusion event
HTLV-1-CSRP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
201466108/201496980 (Hg38)
End
201466108/201496980 (Hg38)
Orient
+
Location type
Intronic
Target gene
CSRP1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-124-3p ; hsa-mir-122-5p ; hsa-mir-599 ; hsa-mir-192-3p ; hsa-mir-3161 ; hsa-mir-6807-5p ; hsa-mir-1277-5p ; hsa-mir-767-5p ; hsa-mir-502-3p ; hsa-mir-501-3p ; hsa-mir-5096 ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-4315 ; hsa-mir-1306-5p ; hsa-mir-587 ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-519d-5p ; hsa-mir-6884-3p ; hsa-mir-1207-3p ; hsa-mir-3145-5p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p
Nearest miRNA
hsa-mir-101-1/Upstream/2637827; hsa-mir-1182/Downstream/222528;
Nearest TSS
ENST00000473358/Upstream/407; ENST00000454651/Downstream/9723;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/15003, chr1-CpG: 72/Downstream/9777
Upstream sequence
cagggaggctggtaaggcactgcctggcaatgctctccttcttaactcagggtggttgtcatatgggggctcactttataattattctttgaactgtaca
Downstream sequence
tgtaggttttgtgcacacttttgtatataagctatagctcacCACAAGAAAAAAGTTTTTTTTGTTTTGTTTTGTTTTTTAAATGCAGggctgggcatgg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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