Basic Information
VIS ID
TVIS44002523
Fusion event
HTLV-1-METTL25 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
82783122/82389343 (Hg38)
End
82783122/82389343 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
METTL25
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-let-7c-5p
Nearest miRNA
hsa-let-7i/Upstream/1230882; hsa-mir-1178/Downstream/4355725;
Nearest TSS
ENST00000382841/Upstream/15316; ENST00000550298/Downstream/10016;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/30376, chr12-CpG: 79/Downstream/297540
Upstream sequence
ggctgttgagaacttcacctgtggctagtggagcatagaatgttaattttcaattatatttgattttagtgtaaattgcaataatcacatgtggttagca
Downstream sequence
gctactatattagacagcacagGTAAtgaaatgactgtttaagtttttttccccacttttctattgggtgattctttttgtattgatttataggagtttg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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