Basic Information
VIS ID
TVIS44002540
Fusion event
HTLV-1-C9orf40 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
77567190/74952274 (Hg38)
End
77567190/74952274 (Hg38)
Orient
-
Location type
Exonic
Target gene
C9orf40
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-106b-5p ; hsa-let-7c-5p ; hsa-mir-20a-5p ; hsa-mir-653-5p ; hsa-mir-223-3p ; hsa-mir-4697-3p ; hsa-mir-6876-3p ; hsa-mir-626 ; hsa-mir-570-3p ; hsa-mir-4302 ; hsa-mir-6733-3p ; hsa-mir-4742-5p ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-4796-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-106a-5p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-4673 ; hsa-mir-4645-5p
Nearest miRNA
hsa-mir-101-2/Upstream/4142190; hsa-let-7a-1/Downstream/9017474;
Nearest TSS
ENST00000422679/Upstream/64180; ENST00000455609/Downstream/612;
Nearest CpG islands
chr9-CpG: 152/Target, None/Upstream, None/Downstream
Upstream sequence
CCAGCCCCTACCTGGCGCGATGCGACCCCCCAGTCTccccgcgggggtcctgcgcgccccgccccgtcgtcgccaccgccccccgggagccgggcgcccg
Downstream sequence
ggAGCTCCTCCCCCGGCCCCGGCAGTACGGGCGGCGGCGGCAGCGGCGGATCGCCTGTCTCCAGACCGTGGTCCTCACGCTCCTGGCCGCTCGGGGCGCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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