Basic Information
VIS ID
TVIS44002568
Fusion event
HTLV-1-FGF11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
7344969/7441650 (Hg38)
End
7344969/7441650 (Hg38)
Orient
+
Location type
Intronic
Target gene
FGF11
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-24-3p
Nearest miRNA
hsa-mir-1253/Upstream/218271; hsa-mir-10226/Downstream/646406;
Nearest TSS
ENST00000595228/Upstream/877; ENST00000574054/Downstream/1677;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/941, chr17-CpG: 46/Downstream/3305
Upstream sequence
CAGGGCACCCCAGAGGATACCAGCTCCTTCAGTGAGAGGGGAAGCTGGCTGCAGGGTGGGAAGGGGGAGAATGGGGACAGGAGATGACAATCCTATTCCC
Downstream sequence
TCTTCAGCTTCTGTTGCCATTGATCCGTCTTCCTGACCTCTAAGGGAAAAAGTGGAGCTGGGATGAGGGGAGCTCAGGTGAGGGTCAGAGGCCTGGGTAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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