Basic Information
VIS ID
TVIS44002572
Fusion event
HTLV-1-MIR99AHG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17757794/16385474 (Hg38)
End
17757794/16385474 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA21A
Target gene
MIR99AHG
Nearest miRNA
hsa-mir-10396a/Upstream/2661200; hsa-let-7c/Downstream/153615;
Nearest TSS
ENST00000624081/Upstream/54870; ENST00000435697/Downstream/33606;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/654990, chr21-CpG: 138/Downstream/1127014
Nearest cancer related gene
MIR99AHG(OG, No orient, 0)
Upstream sequence
GAAATATATAAATATCTTCAAACTACTGTTCTATTTCTTATACTTTTTGAAACTGATCTAGTGATTTGCTTTTGATTTCCTATTGCAGTGTTTGATTGTC
Downstream sequence
ATCTAACTGATTATTTTAAGTGATTTAATTATATTATAAGATGAATAAAATTCAGGCTTCCAGTTAACTAACTAGCTTTTGTTCCCTGAAGAAATTGGCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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