Basic Information
VIS ID
TVIS44002602
Fusion event
HTLV-1-PRICKLE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
64319088/64333412 (Hg38)
End
64319088/64333412 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRICKLE2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-5089-3p ; hsa-mir-5093 ; hsa-mir-4468 ; hsa-mir-219a-2-3p ; hsa-mir-219b-3p ; hsa-mir-4680-5p ; hsa-mir-4680-3p ; hsa-mir-6826-5p ; hsa-mir-4496 ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-4724-5p ; hsa-mir-3646 ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-4272 ; hsa-mir-6074 ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-5692a ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-203a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p
Nearest miRNA
hsa-let-7g/Upstream/3715542; hsa-mir-12124/Downstream/2892052;
Nearest TSS
ENST00000440867/Upstream/65238; ENST00000487097/Downstream/111819;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/65269, chr3-CpG: 73/Downstream/111497
Nearby gene
PRICKLE2(-107957) ;
Upstream sequence
ATATAAAAGAAGAATTTCAGTTCCAGAATAGAAATAGCATCCCTTTtactgagatctttgcattcattttccaacctaatcttcatagtagtccctcaag
Downstream sequence
acggatataactatccccattttcggatgaggaaaccaagactcagagagtttaaataacttgtccaatttttcacaactaataagtagcagaggcaaga
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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