Basic Information
VIS ID
TVIS44002607
Fusion event
HTLV-1-KLF8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
56245496/56219063 (Hg38)
End
56245496/56219063 (Hg38)
Orient
-
Location type
Intronic
Target gene
KLF8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-7977 ; hsa-mir-450a-1-3p ; hsa-mir-342-3p ; hsa-mir-383-3p ; hsa-mir-1228-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-6785-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-8075 ; hsa-mir-93-3p ; hsa-mir-6826-3p ; hsa-mir-4680-5p ; hsa-mir-1236-3p ; hsa-mir-6832-3p ; hsa-mir-6515-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-3914 ; hsa-mir-5571-5p ; hsa-mir-3152-5p ; hsa-mir-6809-3p ; hsa-mir-498 ; hsa-mir-6836-3p ; hsa-mir-4753-3p ; hsa-mir-6778-3p ; hsa-mir-4772-3p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-135a-5p
Nearest miRNA
hsa-let-7f-2/Upstream/767481; hsa-mir-105-1/Downstream/7566939;
Nearest TSS
ENST00000429181/Upstream/310940; ENST00000476898/Downstream/13358;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/729952, chrX-CpG: 17/Downstream/13455
Nearby gene
KLF8(+13326) ;
Nearest cancer related gene
KLF8(OG, No orient, 0)
Upstream sequence
aaatagtgtcttcaaaattgtggcatattttaaattttcacactaaacaaaacaacatttttttaacaagcacacataatagaattctatttacaagatg
Downstream sequence
ataaaaatattcttatatataaatataaatgtcataatgtgctgtagaagtacgtgtagtccaatcataggctccacgtttgaatttgtatgatgaaata
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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