Basic Information
VIS ID
TVIS44002619
Fusion event
HTLV-1-STXBP5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
147570411/147249275 (Hg38)
End
147570411/147249275 (Hg38)
Orient
+
Location type
Intronic
Target gene
STXBP5
miRNAs that regulate target gene
hsa-mir-21-5p
Nearest miRNA
hsa-mir-10398/Upstream/6565392; hsa-mir-1202/Downstream/3853400;
Nearest TSS
ENST00000381078/Upstream/44661; ENST00000367475/Downstream/77898;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/44563, chr6-CpG: 23/Downstream/157671
Upstream sequence
gcacctctaacctacagaaataataaatgggtattcttttaagccattaaatttgtgataccttgttacaaaatcagtaaaaaaaaaaaatacaCCTGGT
Downstream sequence
ATTAGtttggtacctgaaagtggaatactactgtaacaaatatctgaatatgtggaagtcactttggaacttcgcagtgagtagaacctggaagaatttc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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