Basic Information
VIS ID
TVIS44002637
Fusion event
HTLV-1-CMTM4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
66648800/66614897 (Hg38)
End
66648800/66614897 (Hg38)
Orient
-
Location type
UTR3
Target gene
CMTM4
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-375 ; hsa-mir-186-5p ; hsa-mir-124-3p ; hsa-mir-24-3p ; hsa-mir-503-5p ; hsa-mir-125b-5p ; hsa-mir-23b-3p ; hsa-mir-943 ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-5584-5p ; hsa-mir-4513 ; hsa-mir-5582-3p ; hsa-mir-5000-3p ; hsa-mir-4436a ; hsa-mir-4700-3p ; hsa-mir-3158-5p ; hsa-mir-5703 ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-873-5p ; hsa-mir-4768-3p ; hsa-mir-922 ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-583 ; hsa-mir-1257 ; hsa-mir-1283 ; hsa-mir-3607-5p ; hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-5587-5p ; hsa-mir-452-3p ; hsa-mir-20a-3p ; hsa-mir-129-5p ; hsa-mir-7113-5p
Nearest miRNA
hsa-mir-1225/Upstream/8842545; hsa-mir-11401/Downstream/587424;
Nearest TSS
ENST00000527434/Upstream/5525; ENST00000569274/Downstream/6878;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/9239, chr16-CpG: 133/Downstream/81025
Upstream sequence
CAATAGTTATTAACGATTAGTGTTGAGAAAATTATTTCCCTCTACATACAAAAATACAGATTTGAACACTATGAAAAAGATCAAGACAAGTACCATGAAA
Downstream sequence
AACTGGTCCTTCAAATGAAAGGGGGAAAATTGAGGGCAATGTGAGGCTTTGCCTGCTGTCGGGGACAAATCAATAGCAGCAAAGCTTTGGGGCCCCAACC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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