Basic Information
VIS ID
TVIS44002674
Fusion event
HTLV-1-NIPAL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
24792780/24466290 (Hg38)
End
24792780/24466290 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
NIPAL3
miRNAs that regulate target gene
hsa-mir-1303 ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-6134 ; hsa-mir-7854-3p ; hsa-mir-7-5p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-6807-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-1343-5p ; hsa-mir-3150a-3p ; hsa-mir-3175 ; hsa-mir-3675-5p ; hsa-mir-496 ; hsa-mir-552-5p ; hsa-mir-6763-5p ; hsa-mir-6825-5p ; hsa-mir-6890-5p ; hsa-mir-939-5p
Nearest miRNA
hsa-mir-12136/Upstream/537143; hsa-mir-101-1/Downstream/453055;
Nearest TSS
ENST00000473358/Upstream/10124; ENST00000374393/Downstream/36061;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/49741, chr1-CpG: 108/Downstream/36085
Upstream sequence
ctgtggaacagaaacaatttcacagaacatcagcagcagacaaggccactctgcagctgtgatggatcaggacacaagcaggTGGAATGGGAAGAAAAGG
Downstream sequence
GTTTTTTTCCtaaaattaaaaataaataaataaataaaaGAacacaaacaggactactctgctagcctgactaaacatagacaaaaaatggacattgtcc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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