Basic Information
VIS ID
TVIS44002677
Fusion event
HTLV-1-MTR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q43
Reference genome
GRCh37/hg19
Start
236982711/236819411 (Hg38)
End
236982711/236819411 (Hg38)
Orient
+
Location type
Intronic
Target gene
MTR
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-106b-5p ; hsa-mir-10a-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-218-5p ; hsa-mir-4715-3p ; hsa-mir-3064-3p ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-5585-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-4635
Nearest miRNA
hsa-mir-101-1/Upstream/966351; hsa-mir-3123/Downstream/651708;
Nearest TSS
ENST00000473358/Upstream/23796; ENST00000470570/Downstream/16205;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/23509, chr1-CpG: 169/Downstream/222415
Upstream sequence
tttgctgtttccagaatggtatatagttgagaccacatagtatgtagccttttcacattggcttctttcacttagtgatcttcatttaaggttcattcat
Downstream sequence
gtctttgtaggctcgatagcttatttctttttaacgctaaataatattccgttgcgaagatgtacggtgggtttttttcccattcatgtattgaagacca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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