Basic Information
VIS ID
TVIS44002681
Fusion event
HTLV-1-UVRAG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
75670332/75959288 (Hg38)
End
75670332/75959288 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
UVRAG
miRNAs that regulate target gene
hsa-mir-203a-3p ; hsa-mir-92a-3p ; hsa-mir-130b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-32-5p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-33a-5p ; hsa-mir-301a-3p ; hsa-mir-205-5p ; hsa-mir-183-5p ; hsa-mir-203a-5p
Nearest miRNA
hsa-mir-10392/Upstream/624102; hsa-let-7a-2/Downstream/3442734;
Nearest TSS
ENST00000527297/Upstream/28428; ENST00000530501/Downstream/2175;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/143407, chr11-CpG: 79/Downstream/205105
Nearest cancer related gene
UVRAG(TSG, No orient, 0)
Upstream sequence
agtcagtctgtcctttgaagctttgaagccaggcattgacttctcctctctagctatgaaagtcctaggtggcatcttatttcaacagaaggctgtttca
Downstream sequence
tctatgttgaaaatctgttgtttagtataaccaccttcattgatgatcttagctagagctactgagtaacttattgcagcttctccattagcacttcctg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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