Basic Information
VIS ID
TVIS44002683
Fusion event
HTLV-1-COG3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.13
Reference genome
GRCh37/hg19
Start
46089186/45515051 (Hg38)
End
46089186/45515051 (Hg38)
Orient
+
Location type
Intronic
Target gene
COG3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-2276/Upstream/1318851; hsa-mir-1267/Downstream/4481364;
Nearest TSS
ENST00000623511/Upstream/23582; ENST00000486940/Downstream/1096;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/49505, chr13-CpG: 63/Downstream/198096
Upstream sequence
TTGTGTACTTTTATCTTAAAAAGTGATCAGTGAAAATGGATTAATGTCTTAAACAGTTTTTTAAGGCAAGAAATTGTTCTTACATACTTAAACTGAGCAC
Downstream sequence
CTGTCAACAAATTAACATGATACTATTTGCTGGATTACAATAGCTTTAGTGAAGTAATAAAATCTATATGATACAATTTTTGGCATCAGAGTTGTTAGGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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