Basic Information
VIS ID
TVIS44002687
Fusion event
HTLV-1-FOXN3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.11
Reference genome
GRCh37/hg19
Start
90064543/89598199 (Hg38)
End
90064543/89598199 (Hg38)
Orient
+
Location type
Intronic
Target gene
FOXN3
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-21-5p ; hsa-mir-92b-3p ; hsa-mir-210-3p ; hsa-mir-4777-3p ; hsa-mir-5096 ; hsa-mir-6790-5p ; hsa-mir-4658 ; hsa-mir-197-3p ; hsa-mir-4477a ; hsa-mir-921 ; hsa-mir-1257 ; hsa-mir-6073 ; hsa-mir-548au-3p ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-34a-5p ; hsa-mir-3659 ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-16-1-3p ; hsa-mir-425-5p ; hsa-mir-3174 ; hsa-mir-7153-3p ; hsa-mir-562 ; hsa-mir-6878-3p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-4684-3p ; hsa-mir-203a-3p ; hsa-mir-1245b-3p ; hsa-mir-888-5p ; hsa-mir-409-3p ; hsa-mir-335-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-890 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-374a-3p ; hsa-mir-3686 ; hsa-mir-3607-3p ; hsa-mir-34c-3p ; hsa-mir-4762-3p ; hsa-mir-3192-3p ; hsa-mir-29a-5p ; hsa-mir-3920 ; hsa-mir-6509-5p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-370-5p ; hsa-mir-6867-5p
Nearest miRNA
hsa-mir-1260a/Upstream/12331909; hsa-mir-1185-1/Downstream/4350027;
Nearest TSS
ENST00000550708/Upstream/21983; ENST00000553569/Downstream/20931;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/180265, chr14-CpG: 57/Downstream/20822
Upstream sequence
aaacatgcatccttaacttatcaatgacaacacaacttcgttatcacttcctgtacactacaaggaacttagaatgatttaacttcattaacttctttgg
Downstream sequence
atttatgttctacttttaccatgtatgttattccctacatattttaaactccacaaaacataataattattattttataaagtcaatatttatttatatt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate