Basic Information
VIS ID
TVIS44002693
Fusion event
HTLV-1-CYP2S1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
41710649/41204744 (Hg38)
End
41710649/41204744 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CYP2S1
miRNAs that regulate target gene
hsa-mir-147a
Nearest miRNA
hsa-mir-10395/Upstream/834837; hsa-let-7e/Downstream/664883;
Nearest TSS
ENST00000633603/Upstream/3451; ENST00000594880/Downstream/14459;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/11467, chr19-CpG: 56/Downstream/21357
Upstream sequence
tggagtgcactggcgtgatctcggctcactgcaacctccgcctcccaggttcaagcaattctcttgcctcagcctcctgggtagctgggattacaggtgt
Downstream sequence
atgccaccacacccggctaatttttgtctttttagtagagatgggttttcaccatgttggtcaggctggtctcaaactcctgacctcatgaactgcctgc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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