Basic Information
VIS ID
TVIS44002729
Fusion event
HTLV-1-KDM4C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
7045094/7045094 (Hg38)
End
7045094/7045094 (Hg38)
Orient
+
Location type
Intronic
Target gene
KDM4C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-409-3p ; hsa-mir-432-5p
Nearest miRNA
hsa-mir-101-2/Upstream/1037190; hsa-let-7a-1/Downstream/11528212;
Nearest TSS
ENST00000422679/Upstream/31306; ENST00000495890/Downstream/4098;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/286222, chr9-CpG: 43/Downstream/754261
Nearest cancer related gene
KDM4C(OG, No orient, 0)
Upstream sequence
ccaaggacttggaattgtctattagatactgtgacttggaggGGAGGCTAGGAAGAGTGAATATCTTCTTGTGATGGTGGAGAATCTTAAAATCCATTTA
Downstream sequence
AAATCTTGAGCCTACACATTGTATTTTAGAAGACTTTTTCCTCTTGTTAGATTAGTGCTCTAGAACATGTGTACCTGTTAATGATCCTAATCAGGTGCTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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