Basic Information
VIS ID
TVIS44002736
Fusion event
HTLV-1-HEPH integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q12
Reference genome
GRCh37/hg19
Start
65389420/66169578 (Hg38)
End
65389420/66169578 (Hg38)
Orient
-
Location type
Intronic
Target gene
HEPH
miRNAs that regulate target gene
hsa-mir-4786-3p ; hsa-mir-873-3p ; hsa-mir-3613-3p ; hsa-mir-449b-3p ; hsa-mir-548c-3p
Nearest miRNA
hsa-let-7f-2/Upstream/150599; hsa-mir-105-1/Downstream/3853279;
Nearest TSS
ENST00000429181/Upstream/5213; ENST00000425114/Downstream/329;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/347116, chrX-CpG: 27/Downstream/1374385
Upstream sequence
GTCTAACGTCCTGTCTTATGCATTGAAGTGAGAGGTTAGAATCTTGGGTCTGATTCTGACTCAGGATTAGACCTATGAAATGAATTTATGAATAGCCTTG
Downstream sequence
GGAATCAGCAGACAACATTTCTTCTGAGAAGTTCAAAATACTTCCCTCACATACTGTCATTTAtttttggttcattgttaacttttgaagtataatacac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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