Basic Information
VIS ID
TVIS44002740
Fusion event
HTLV-1-FAM81B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
94730378/95394674 (Hg38)
End
94730378/95394674 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
FAM81B
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-4756-3p ; hsa-mir-802
Nearest miRNA
hsa-mir-10397/Upstream/1773886; hsa-mir-103a-1/Downstream/684464;
Nearest TSS
ENST00000502646/Upstream/1822; ENST00000513110/Downstream/34005;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/109257, chr5-CpG: 61/Downstream/160029
Upstream sequence
CTTAGGAAAGTTTCCATAACGTGGCCACCTGAGTGCCCAGTGAATCAGTAGATCCATTCTCGAGGGGAAGACGTGGCTTAACAGCATTAGACCCATTGCA
Downstream sequence
GACCCCATTCAGCAATGCGGGGAGGGTACAAGCTCTCTCCTGGGGGTTCACAGGCTCCCTCGTGAGCAGCCTCGAGCCTTTTCTGCCTGCCCACCACCAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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