Basic Information
VIS ID
TVIS44002748
Fusion event
HTLV-1-ITPR3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
33620022/33652245 (Hg38)
End
33620022/33652245 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
ITPR3
miRNAs that regulate target gene
hsa-mir-1226-3p ; hsa-mir-877-3p ; hsa-mir-23b-3p ; hsa-mir-96-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1236/Upstream/213808; hsa-mir-10398/Downstream/45883;
Nearest TSS
ENST00000381078/Upstream/30866; ENST00000526556/Downstream/46412;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/18289, chr6-CpG: 20/Downstream/35944
Upstream sequence
GCCAGGAGGAACCTCTGTCCTGTTTCTAGATGCGCCATATCCTCTCCCACCTCCTGCTCTTTCCTCCAGTTGTGTGCCTCGTAACCTCTTCCTCCCTCCA
Downstream sequence
AGGCTAAATCAAACCCTACCTCCTTATACAGGAGGAAGTAATTTCTGGGTTGATGTATGCATCCGGCAGATTCATGCTGAGCCAACAGGTTAGGGGCTGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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