Basic Information
VIS ID
TVIS44002753
Fusion event
HTLV-1-COL9A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
70958226/70248523 (Hg38)
End
70958226/70248523 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
COL9A1
miRNAs that regulate target gene
hsa-mir-1273h-3p ; hsa-mir-4771 ; hsa-mir-3166 ; hsa-mir-1324 ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-4789-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-10398/Upstream/12858311; hsa-mir-10524/Downstream/1128437;
Nearest TSS
ENST00000381078/Upstream/2220; ENST00000418403/Downstream/6088;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/380843, chr6-CpG: 61/Downstream/33814
Upstream sequence
CTCCAACCCACATGCCTCAGTAGCTCATTTCTTCTTCTCAGCTTGTTTTAGATTTGCAGGAAAAACTGATCAAACGTGTGAGGCATTGTTAAAAATGTAT
Downstream sequence
GAAGTTATCTACAAAACTGAATTTAATGATGTAAAGTGAAAGAACAAATGTGTCTTTCAGTAAGTGGATTTGGTGTTAAAACTCTGCTCCAGAACTATAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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