Basic Information
VIS ID
TVIS44002757
Fusion event
HTLV-1-DSG2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
29090206/31510243 (Hg38)
End
29090206/31510243 (Hg38)
Orient
+
Location type
Intronic
Target gene
DSG2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-let-7b-5p ; hsa-mir-15b-5p ; hsa-mir-126-5p ; hsa-mir-944 ; hsa-mir-494-3p ; hsa-mir-510-3p ; hsa-let-7f-2-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-556-3p ; hsa-mir-5589-3p ; hsa-mir-5700 ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-8064 ; hsa-mir-215-3p ; hsa-mir-3607-5p ; hsa-mir-6760-3p ; hsa-mir-603 ; hsa-mir-8485
Nearest miRNA
hsa-mir-1-2/Upstream/1211283; hsa-mir-122/Downstream/4081494;
Nearest TSS
ENST00000575820/Upstream/12023; ENST00000432547/Downstream/46662;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/11680, chr18-CpG: 145/Downstream/174466
Upstream sequence
ACCACTGGCAAGTGCCACGTCCTCTGTGTTTGAGTTCTAAAGATAGTCCGTTGAGCACACTGCTTACCTTCTAGTAATTTCTCGCTGAATGGACATTAGA
Downstream sequence
AGCCATTATAGTGACTGAAAGTTGAAATAATGTTTTAAACTAATTTGTATTTCTCTACATCCATTTTTAATAAGGTATCTCTTAGTCTGATCTATTAAAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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