Basic Information
VIS ID
TVIS44002761
Fusion event
HTLV-1-PEX7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
137192341/136871203 (Hg38)
End
137192341/136871203 (Hg38)
Orient
+
Location type
Intronic
Target gene
PEX7
miRNAs that regulate target gene
hsa-mir-4668-5p ; hsa-mir-4263 ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-548n
Nearest miRNA
hsa-mir-10398/Upstream/1631947; hsa-mir-1202/Downstream/1564010;
Nearest TSS
ENST00000381078/Upstream/48618; ENST00000331858/Downstream/51061;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/47896, chr6-CpG: 285/Downstream/49974
Upstream sequence
GGACAAGTTTTAGCAGTTGaaaaatatgctctatgtatattttagagtgattatgagaatgaaataaggtaatgtagtgaaagtactttgcaaactaagt
Downstream sequence
gctggtcaaatgtaGTTATATATGTGTATTTAACTATTAAAGTGCGATAAGACAAACACTGAAGAAATGTAATTGCAAAGGTCAACTTATTAAGTACATT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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