Basic Information
VIS ID
TVIS44002768
Fusion event
HTLV-1-ATP6V0A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
40665222/42513204 (Hg38)
End
40665222/42513204 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP6V0A1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-let-7b-5p ; hsa-mir-335-5p
Nearest miRNA
hsa-mir-1180/Upstream/18374; hsa-mir-10226/Downstream/984;
Nearest TSS
ENST00000595228/Upstream/5869; ENST00000588806/Downstream/238;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/54190, chr17-CpG: 76/Downstream/22811
Upstream sequence
AGGAAAACTGGGACAAAGGGAGCTTGAGGAAAACGAAAACAAACAAGAAACTGGAGATATGCTATTTAGTCTTAACCCAAACAGATATGCTGTTTGGCCT
Downstream sequence
TAACCCATGTGGAAATTTGTAAACTTTGTCAGGATTTCCCTGTGCATGGTGGTGAAATCATGTAGGGAAAAAAAAATTCACCGTGTAATCTCTTTAGAAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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