Basic Information
VIS ID
TVIS44002791
Fusion event
HTLV-1-CAMKK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
121681474/121243671 (Hg38)
End
121681474/121243671 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA12E
Target gene
CAMKK2
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-185-5p ; hsa-mir-100-5p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5100 ; hsa-mir-644a ; hsa-mir-3911 ; hsa-mir-7847-3p ; hsa-mir-8078 ; hsa-mir-4294 ; hsa-mir-1289 ; hsa-mir-3664-3p ; hsa-mir-4330 ; hsa-mir-1288-5p ; hsa-mir-9500 ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-5584-5p ; hsa-mir-6854-5p ; hsa-mir-9-5p
Nearest miRNA
hsa-let-7i/Upstream/520405; hsa-mir-3612/Downstream/200602;
Nearest TSS
ENST00000382841/Upstream/21339; ENST00000557474/Downstream/16871;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/33210, chr12-CpG: 27/Downstream/30372
Upstream sequence
gacacagaaggccacgtagtgtatgacgccatttatacgaaacgtccagaataggcaaatccatacctattctgagtggttactggggtgggggagttgg
Downstream sequence
atggggacagctaaggagtgtagggtgtcttcttgggctgatgaaaatgtcgtaaagttgacggtggtaatggctgcagaagtctgtattagaaaccact
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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