Basic Information
VIS ID
TVIS44002811
Fusion event
HTLV-1-ARL6IP5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
69136627/69087476 (Hg38)
End
69136627/69087476 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARL6IP5
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-145-5p ; hsa-mir-31-3p
Nearest miRNA
hsa-let-7g/Upstream/38441; hsa-mir-12124/Downstream/2454494;
Nearest TSS
ENST00000440867/Upstream/2434; ENST00000460597/Downstream/35090;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/2148, chr3-CpG: 62/Downstream/298299
Nearest cancer related gene
ARL6IP5(TSG, No orient, 0)
Upstream sequence
TTTGCAAAGAAGCAGGAGGGCATCTTATCTGGTGATCTAGTTATGGAGGTATTTTCTTGAGGTAACTTAGATGTGGGGCAAAGTTTGACACAGACCaata
Downstream sequence
attaaaaaaaaaaaaaaGTCTATTTTCTTCAGACATGTGTGCTGCCCAGACCAGGCACAAGCTCAGACAGCCTTGCTGCTTTTGATAGAATCCATTTTTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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