Basic Information
VIS ID
TVIS44002829
Fusion event
HTLV-1-SLC25A21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
37568962/37099757 (Hg38)
End
37568962/37099757 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLC25A21
miRNAs that regulate target gene
hsa-mir-625-5p ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-335-3p ; hsa-mir-3611 ; hsa-mir-4289 ; hsa-mir-4666a-3p
Nearest miRNA
hsa-mir-208a/Upstream/147366; hsa-mir-1185-1/Downstream/10661238;
Nearest TSS
ENST00000550708/Upstream/290886; ENST00000556667/Downstream/72131;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/432614, chr14-CpG: 61/Downstream/72270
Upstream sequence
TTTATAGAATAAGAATGTTagttactatttgctgtgcaccaacaatggcaggctccatattgggaactttaaatgtatctttaaccttcgcattgagtga
Downstream sequence
ggtaagcataatattttcctccttttccagattcagaacccggagctctgagagagtaagtgattttcctaaaatcatatgggtggtaagaacctaggtg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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