Basic Information
VIS ID
TVIS44002848
Fusion event
HTLV-1-ANKRD17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
74088587/73222870 (Hg38)
End
74088587/73222870 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANKRD17
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-424-5p ; hsa-mir-186-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-549a ; hsa-mir-4699-3p ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-885-5p ; hsa-mir-6504-3p
Nearest miRNA
hsa-mir-12113/Upstream/6945942; hsa-mir-1243/Downstream/3350698;
Nearest TSS
ENST00000502981/Upstream/68935; ENST00000502790/Downstream/169;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/152937, chr4-CpG: 62/Downstream/35818
Upstream sequence
ACAAAATAATTATAGACGTCTATAGTAATCATGTGAACCAGTCTGAAACATTCTCACACGGAATAGGTCTGACCGTGTCTTGCTTTTATGCTCTGCTTCT
Downstream sequence
CTTTGCTCTCTCCTCTAATCTATTCATCTGTAAAATAATTCCGGCAGATAAGATTTCTTTGTTCAGATTTCAACTTTCATTTCACTTACAAACCTAGCCC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate