Basic Information
VIS ID
TVIS44002851
Fusion event
HTLV-1-ADGRL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
62358701/61492983 (Hg38)
End
62358701/61492983 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADGRL3
miRNAs that regulate target gene
hsa-mir-20a-5p
Nearest miRNA
hsa-mir-12113/Upstream/570299; hsa-mir-1243/Downstream/4783841;
Nearest TSS
ENST00000502981/Upstream/64762; ENST00000509089/Downstream/4138;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/289900, chr4-CpG: 60/Downstream/1856146
Nearby gene
ADGRL3(No orient, 4138)
Upstream sequence
TAAATGTAAACATTATTGATGCAAATTAGGTCATTTTAATCAACTTTACTTTTAAATTTTGGATATTGTGAAGAATAGTGAACTTAGTTTTGTTTTAAGA
Downstream sequence
CAGATAACCACTAAGATTTTTATAAGAAAAGAAATTTGTTTGGTGAAGTTAATGACAACACTTCAATGGAAAAATCATCATAAAATGTTTTCTTTTAAAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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