Basic Information
VIS ID
TVIS44002854
Fusion event
HTLV-1-ANKS1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
35033460/35065683 (Hg38)
End
35033460/35065683 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
ANKS1A
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-487a-5p ; hsa-mir-509-3p ; hsa-mir-487b-5p ; hsa-mir-4781-3p ; hsa-mir-6740-5p ; hsa-mir-744-3p ; hsa-mir-1263 ; hsa-mir-150-3p ; hsa-mir-4777-3p ; hsa-mir-4684-3p ; hsa-mir-622 ; hsa-mir-4307 ; hsa-mir-513a-5p ; hsa-mir-6862-5p ; hsa-mir-4253 ; hsa-mir-3945 ; hsa-mir-6847-3p ; hsa-mir-5196-3p ; hsa-mir-6854-5p ; hsa-mir-1205 ; hsa-mir-125a-3p ; hsa-mir-3197 ; hsa-mir-34a-5p ; hsa-mir-34c-5p ; hsa-mir-3665 ; hsa-mir-4316 ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-4710 ; hsa-mir-548au-3p ; hsa-mir-558 ; hsa-mir-6087 ; hsa-mir-657 ; hsa-mir-6717-5p ; hsa-mir-6765-5p
Nearest miRNA
hsa-mir-1236/Upstream/824947; hsa-mir-10398/Downstream/404825;
Nearest TSS
ENST00000381078/Upstream/7435; ENST00000274938/Downstream/55362;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/175796, chr6-CpG: 75/Downstream/75341
Upstream sequence
GGGACTGGCAGCCACGTCCCTGGACCTGGAGTGGTGCTTCCACCTCCCAATCTTCCCTTCCCAGGAAGATGCAGCCCCTGGGGCTCATGCTCATGTGCCC
Downstream sequence
TCACAAGGTTGGAGCCTGGCACTGGGGCCCATCAGGCTGGGTGAGTGCATCACCCCTGGGCTGGTCCAGGTCAGACGTCCACCCACTGCATGTTGGGAGC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate