Basic Information
VIS ID
TVIS44002876
Fusion event
HTLV-1-PCNX1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
71455566/70988849 (Hg38)
End
71455566/70988849 (Hg38)
Orient
+
Location type
Intronic
Target gene
PCNX1
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-17-5p ; hsa-mir-3941 ; hsa-mir-374a-5p ; hsa-mir-510-3p ; hsa-mir-6831-3p ; hsa-mir-4637 ; hsa-mir-590-3p ; hsa-mir-4282 ; hsa-mir-2355-3p ; hsa-mir-4646-3p ; hsa-mir-3912-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-5688 ; hsa-mir-495-3p
Nearest miRNA
hsa-mir-208a/Upstream/3546919; hsa-mir-1185-1/Downstream/1527971;
Nearest TSS
ENST00000550708/Upstream/10471; ENST00000554707/Downstream/24182;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/80164, chr14-CpG: 116/Downstream/331289
Upstream sequence
TAATCTGTTCCGCCAGTCCCAAGAAAGCATTTGAAGAGCTTTGTTTTTCTTTTCCTTTCTGTTTCTTTCCTATACATTTAAGCCCTTTTTGGCTTTTTCT
Downstream sequence
GCATGTGACCATGAGCCTGTTGCATTATGCATGCTTTATGTTGCACTGTTTAAGTAAAATGATCAGATTGGTTTAGTCAATTTTAAATCACTTGAGGGCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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