Basic Information
VIS ID
TVIS44002883
Fusion event
HTLV-1-ZNF714 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
21269409/21086603 (Hg38)
End
21269409/21086603 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF714
miRNAs that regulate target gene
hsa-mir-331-3p ; hsa-mir-222-3p ; hsa-mir-155-5p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-3678-3p ; hsa-mir-2467-3p ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3919 ; hsa-mir-548t-5p ; hsa-mir-548az-5p
Nearest miRNA
hsa-mir-10395/Upstream/687249; hsa-let-7e/Downstream/14036097;
Nearest TSS
ENST00000633603/Upstream/2583; ENST00000599296/Downstream/55421;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3976, chr19-CpG: 18/Downstream/376923
Upstream sequence
gtttccatggcatttgtaaactgttacgacactggtaagagtgtagcagtgagggtgaccagaggtcactctcgtcacatcttggttttggtgggtttta
Downstream sequence
tttgacttctttactgcaacctgttttatccgcaaggtctttaaaacttgtatcttttgctgaccttctatcctgtcctgttacttagaatgcctaacca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate