VISDB - VIS Detail

Basic Information

VIS ID

TVIS44002886

Fusion event

HTLV-1-PAPOLG integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr2

Cytoband

p16.1

Reference genome

GRCh37/hg19

Start

61008506/60781371 (Hg38)

End

61008506/60781371 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA2S

Target gene

PAPOLG

miRNAs that regulate target gene

hsa-mir-33a-5p ; hsa-mir-16-5p ; hsa-mir-503-5p ; hsa-mir-548e-5p ; hsa-mir-7158-3p ; hsa-mir-203b-3p ; hsa-mir-31-5p ; hsa-mir-1827 ; hsa-mir-4680-5p ; hsa-mir-4649-3p ; hsa-mir-4538 ; hsa-mir-3123 ; hsa-mir-4453 ; hsa-mir-549a ; hsa-mir-586 ; hsa-mir-5700 ; hsa-mir-33b-5p ; hsa-mir-3658 ; hsa-mir-3653-3p ; hsa-mir-5680 ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-6883-3p ; hsa-mir-561-3p ; hsa-mir-7844-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-4789-5p ; hsa-let-7f-2-3p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-653-5p ; hsa-mir-548s ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-653-3p ; hsa-mir-3926 ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-4711-5p ; hsa-mir-7112-3p ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-1294 ; hsa-mir-4252 ; hsa-mir-455-3p ; hsa-mir-5008-3p ; hsa-mir-5694 ; hsa-mir-6134 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-6737-3p ; hsa-mir-7157-3p ; hsa-mir-7854-3p

Nearest miRNA

hsa-mir-1301/Upstream/393926; hsa-mir-10b/Downstream/1424455;

Nearest TSS

ENST00000437798/Upstream/1817; ENST00000470208/Downstream/604;

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/24636, chr2-CpG: 97/Downstream/99619

Upstream sequence

acctgaaccccagaggcacaggttgcagtgagccgagactgtgccactgcactccagcctgggtgacgagttgagacttcgtctcaaaaaaaaaaaGTAA

Downstream sequence

TTGGTTACTAATAATAAAGTACTAAAGTATAATAAAAGATTTACTTTGCAATACAATTTAAAGCAAATTCATTGTTCCAGGGTAGCATAATTCTCCCATA

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.