Basic Information
VIS ID
TVIS44002889
Fusion event
HTLV-1-SCAF4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
33061373/31689060 (Hg38)
End
33061373/31689060 (Hg38)
Orient
+
Location type
Intronic
Target gene
SCAF4
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-331-3p ; hsa-mir-25-3p ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-185-3p ; hsa-mir-6090 ; hsa-mir-6829-5p ; hsa-mir-744-5p ; hsa-mir-4508 ; hsa-mir-17-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p
Nearest miRNA
hsa-let-7c/Upstream/1313682; hsa-mir-3197/Downstream/1861602;
Nearest TSS
ENST00000624081/Upstream/21813; ENST00000610276/Downstream/4270;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/28716, chr21-CpG: 145/Downstream/42083
Upstream sequence
TCTTCTAGTCAAGTGAAAACAAAACTGTCTTTCTGCTCCGTCCTCTGAGGCTCTGGCTCCATCAGATTCTCCTATATTCTTGAGCTTTTCAATACAttct
Downstream sequence
ccactggaccatgagccccaagattacaccatcttcttctttttaccactgtctagcgcctcccagatgtccagcacatagtaggccctcaatacctgat
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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